PaDEL-Rechallenge is intended to assist the clinical decision making process in the following three ways:
1. Prediction of the clinical outcome of the patient (prognosis)
2. Calculation of the appropriateness of drugs (Reintroduction) and of chemotherapy protocols in combination with doses and the number of administrations of the treatment regimen to be recommended to the patient (Complex Reintroduction)
3. Monitoring of the level of compliance of the protocol to the recommended clinical practice.
The program makes predictions based on analysis of the clinical data, the protocol, and/or the patient’s history.
The program outputs are:
1. Recommendations about re-introduction and complex re-introduction of chemotherapy according to the criteria established in PaDEL (default or expert evaluation) and the PaDEL software algorithm.
2. Compliance levels of the medical protocol.
PaDEL is a PC-based modular decision support system for the analysis of clinical records in order to assist the clinical decision making process.
PaDEL is designed specifically for the following purposes:
1. Clinical records-based knowledge representation.
2. Predictive reasoning for problem solving.
3. Expert reasoning for diagnostic and treatment recommendations.
4. Monitoring of the levels of compliance to clinical protocols.
PaDEL Description:
The main objective of PaDEL is to enable the physician to handle (by means of a “closed loop”) any medical problem in collaboration with the nursing and lab staff of the hospital.
PaDEL is designed in such a way that it meets the requirements of the general architecture of the knowledge-based systems. In particular, PaDEL meets the following requirements of natural and semantical comprehensibility:
1. The representation of medical knowledge is abstract, especially with respect to what is required of a medical file.
2. The representation of medical knowledge and data is domain-specific; this means that “medical abstractions” are used for data representation, and that the data store is tied to the medical domain.
3. No information is interpreted if no justification is given;
4. The language of reasoning is both normative and declarative. This means that reasoning is based on the patient’s medical record according to the goals specified in each request. As a result, the output of the reasoning engine is different according to the type of request made.
5. The representation and use of the knowledge is strongly parameterised; as a result,
The information necessary for PaDEL-Rechallenge Cracked 2022 Latest Version, including the structure of the financial FAPDI model and the set of diagnostic criteria for the assessment of the appropriateness of re-introducing a chemotherapeutic agent, is provided in the PaDEL-Rechallenge Help file.
The Re-introduction Assessment Module consists of the following main components:
1. The Decision Support Tool, which consists of a list of criteria to be used for the assessment of the appropriateness of re-introducing a chemotherapeutic agent.
2. The case-based medication profile.
3. The assessment form.
4. The related counter-check list.
5. The main decision user interface for the case-based user.
6. PaDEL-Rechallenge Help files.
Further information on PaDEL is available in the PaDEL Help file.
PaDEL-Rechallenge will run on any client computer having a Java runtime environment: The application will require a.NET-enabled client that has a Java virtual machine installed and activated.
PaDEL-Rechallenge Limitations: PaDEL-Rechallenge is designed to support the decision making process in the real-world
by providing a decision support instrument that addresses the major factors influencing the clinical decision making process. For this reason, it is not designed to manage chemotherapy re-challenge scenarios that are purely hypothetical, or that are solved as a problem on a university computer (e.g., as in the case of prescribing the re-challenge of an elderly patient in need of life-prolonging chemotherapy).
PaDEL-Rechallenge is a Java-based decision support instrument that is designed to help the clinical decision making process. The program calculates the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR. The program calculates the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR.
PaDEL-Rechallenge is a Java-based decision support instrument that is designed to help the clinical decision making process. The program calculates the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR. The program calculates the appropriateness of re-
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The program is an easy-to-use tool, specifically designed to help in the handling of ADR occurrence in oncology.
PaDEL-Rechallenge contains a group of rules that help to compute the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR.
The information contained in the program is updated whenever new situations are taken into account and help to promote a personalized approach to the adoption of essential decisions on the basis of evidence-based medicine (EBM).
The program calculates the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR.
PaDEL-Rechallenge Contents:
PaDEL-Rechallenge can be used to discover the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR.
PaDEL-Rechallenge calculates the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR.
PaDEL-Rechallenge compares two or more drugs and allows to choose the ones with more advantages in terms of appropriateness.
Two times a day (on the morning and in the evening) a report of the decision is given with the results of the software, without the need of performing any action.
Since 1987, the Italian Cooperative Group on Solid Tumours (CCG) (Istituto Superiore di Sanità , Rome) has been involved in the prevention of ADRs through the elaboration of multidisciplinary guidelines to be followed by all health care professionals who are treating patients. A series of interventions have been carried out on the basis of these guidelines. In particular, during the last few years, PaDEL-Rechallenge has been specifically tailored for use in the clinical context of chemotherapy based on the results of chemotherapeutic protocols. After the beginning of the protocol, the patient population followed by the protocol is calculated through the screening of all patients who are going to be treated with the chemotherapeutic protocol. A database is created and the following characteristics are included: gender, age, tumor location, previous diseases, previous treatments, previous chemotherapy, previous radiotherapy, previous surgery. The clinical characteristics of each patient
PaDEL-Rechallenge Architecture
PaDEL-Rechallenge allows clinical researchers to enter information and receive support for the decision-making process. The program calculates the appropriateness of re-introducing a chemotherapeutic agent following the confirmatory association between the drug and the occurrence of a serious ADR.
Rechallenge is an appropriate intervention in the event of serious ADR if all of the following criteria are satisfied:
Cancer has been diagnosed
Cancer has been treated
Re-introduction of the drug following the ADR is recommended
Re-introduction of the drug is limited to specific patient groups, such as those patients that have failed to respond to the initial treatment or cannot tolerate the initial treatment
The essential re-introduction criteria (limitation of the treatment) are suggested by the investigator at the time the ADR is first observed
The ADR re-introduction assessment is based on the potential impact of the ADR on the patient’s current health status and quality of life, and on the data provided in the patient’s medical file. The ADR re-introduction analysis uses a clinical scoring system to assess the severity and outcome of the ADR, and whether the ADR contributed to the decision to choose a different treatment. Re-introduction is only recommended if the program determines that the ADR score is clinically significant (a score of >3) and the program recommends the re-introduction if the score is >0. For each of these three conditions, the system examines the appropriateness and effectiveness of re-introduction in specific patient sub-groups.
When PaDEL-Rechallenge’s user interface begins a new ADR re-introduction analysis, the program starts with a phase that includes the most frequently considered patient sub-groups. Each identified sub-group is examined separately: PaDEL-Rechallenge will provide a list of recommendations on whether to re-introduce the drug, how often re-introduction should occur, and the patient groups for which re-introduction should be considered. These recommendations are based on:
a pharmacoepidemiological evidence of the ADR
the clinical severity of the ADR (determined by the clinical scoring system)
if the outcome of the first use of the drug was the death of the patient, the outcome of the second use will be considered.
PaDEL-Rechallenge Al
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